‘A Shot of Hope’: What the Vaccine Is Like for Frontline Doctors and Nurses

FARGO, N.D. — As Dr. Rishi Seth rolled up his left sleeve on Monday to receive one of the United States’ first Covid-19 vaccines, he thought of his patients back in the Special Care Unit.

There was the Uber driver who had walked out of the hospital after being on a ventilator. The dying father who said goodbye to his two college-age daughters on a video chat. The four coronavirus patients Dr. Seth had treated just on Monday morning, checking their oxygen levels and reviewing treatment plans before he stripped off his protective gear and joined a first wave of health care workers to get vaccinated in hospitals across the country.

“That’s why today is so emotional,” said Dr. Seth, an internal-medicine physician with Sanford Health in North Dakota, a state that has been ravaged by the virus. “You’re still fighting a battle, but you’re starting to see the horizon.”

Monday’s vaccinations, the first in a staggeringly complicated national campaign, were a moment infused with hope and pain for hundreds of America’s health care workers.

Even as doctors and nurses lined up for the first shots, cheered on their colleagues and joked about barely feeling the prick of the syringe, they also reflected on their grueling months in the trenches of the country’s coronavirus nightmare.

They have scrounged for protective gear and tried treatment after treatment. They have coordinated final phone calls and held patients’ hands when families could not visit. They have come running when alarms warned that a patient was on the edge of dying.

“This is really for all of those patients that unfortunately didn’t make it, all those patients still coming through the doors,” Mona Moghareh, a 30-year-old pharmacist in New Orleans, said on Monday morning as she administered the first shots at the Ochsner Medical Center with journalists and state leaders looking on.

Across the country, hospital auditoriums and conference rooms became makeshift vaccination sites, the first stages for a mammoth, monthslong campaign to vaccinate millions against a rampaging virus that has now killed more than 300,000 people in the United States.

In Fargo, N.D., 155 doctors and nurses with the highest risk of exposure to the virus trickled into a repurposed veterans’ lounge where nurses waited, clustered around a few small round tables. One nurse drew up initial doses of the Pfizer-BioNTech vaccine that recently received emergency authorization. Others asked questions about people’s health history, took their information and then inoculated them with a quick needle prick.

It was over in seconds.

“It is hope,” said Kenzie Frankl, a registered nurse and clinical care leader for Sanford Health in Fargo who volunteered nine months ago to work in the hospital’s coronavirus unit and walked out of the vaccination room with a Day-Glo bandage on her arm.

New coronavirus cases have receded recently in North Dakota — which had the country’s highest rate of infections earlier this fall. But the pandemic is worse than ever in Kansas, where Dr. Maggie Hagan took a break from her rounds in Wichita to get vaccinated.

Dr. Hagan, the director of infection prevention at Ascension Via Christi hospitals in Kansas, has been working 12-hour shifts every day for the past month and a half to manage the surge in hospitalizations. Five units in her hospital have been turned into coronavirus wards. She sees 50 patients each day.

“I almost could cry talking to you now,” she said. “I feel like I didn’t just get a vaccine, I got a shot of hope. It’s hope that this is the beginning of the end of this terrible pandemic that we’ve all been experiencing — but us on the front line have really seen the suffering and the tragedy associated with it.”

Those tragedies are legion. Some patients have to be sedated and flipped on their stomachs to better oxygenate their bodies. Many also require dialysis for kidney failure. Some arrive gasping for air but recover. Others appear stable with a little oxygen, and then crash.

Then there is the personal toll of working 12-hour shift after 12-hour shift sheathed in protective gear, worried that while one patient is treated another may be deteriorating. Some worried about carrying the virus home while others were treated by friends or neighbors as if they had the plague. Some have experienced post-traumatic stress disorder. Many have spent hours after work agonizing over the challenges of treating coronavirus patients.

“They were consumed with what they had seen at work,” said Maggie Hansen, the chief nurse executive of the Memorial Healthcare System in Southern Florida. “They have been taxed by this. Imagine trying to do everything you can to reduce the suffering and it doesn’t always work out and patients die.”

Ms. Hansen described the 5,000 frontline nurses of the Memorial Healthcare System as resilient but physically and mentally exhausted by the pandemic, by being the one to hold the iPad while a dying man in his 60s told his wife that they would meet again in heaven.

In the parking lot of a pharmacy in Miramar, Fla. — where hours earlier, the very first shipments of the vaccine arrived and health care workers were inoculated — Ms. Hansen said the vaccine brought a breath of relief after so much sickness, suffering and death.

The Road to a Coronavirus Vaccine ›

Answers to Your Vaccine Questions

With distribution of a coronavirus vaccine beginning in the U.S., here are answers to some questions you may be wondering about:

    • If I live in the U.S., when can I get the vaccine? While the exact order of vaccine recipients may vary by state, most will likely put medical workers and residents of long-term care facilities first. If you want to understand how this decision is getting made, this article will help.
    • When can I return to normal life after being vaccinated? Life will return to normal only when society as a whole gains enough protection against the coronavirus. Once countries authorize a vaccine, they’ll only be able to vaccinate a few percent of their citizens at most in the first couple months. The unvaccinated majority will still remain vulnerable to getting infected. A growing number of coronavirus vaccines are showing robust protection against becoming sick. But it’s also possible for people to spread the virus without even knowing they’re infected because they experience only mild symptoms or none at all. Scientists don’t yet know if the vaccines also block the transmission of the coronavirus. So for the time being, even vaccinated people will need to wear masks, avoid indoor crowds, and so on. Once enough people get vaccinated, it will become very difficult for the coronavirus to find vulnerable people to infect. Depending on how quickly we as a society achieve that goal, life might start approaching something like normal by the fall 2021.
    • If I’ve been vaccinated, do I still need to wear a mask? Yes, but not forever. The two vaccines that will potentially get authorized this month clearly protect people from getting sick with Covid-19. But the clinical trials that delivered these results were not designed to determine whether vaccinated people could still spread the coronavirus without developing symptoms. That remains a possibility. We know that people who are naturally infected by the coronavirus can spread it while they’re not experiencing any cough or other symptoms. Researchers will be intensely studying this question as the vaccines roll out. In the meantime, even vaccinated people will need to think of themselves as possible spreaders.
    • Will it hurt? What are the side effects? The Pfizer and BioNTech vaccine is delivered as a shot in the arm, like other typical vaccines. The injection won’t be any different from ones you’ve gotten before. Tens of thousands of people have already received the vaccines, and none of them have reported any serious health problems. But some of them have felt short-lived discomfort, including aches and flu-like symptoms that typically last a day. It’s possible that people may need to plan to take a day off work or school after the second shot. While these experiences aren’t pleasant, they are a good sign: they are the result of your own immune system encountering the vaccine and mounting a potent response that will provide long-lasting immunity.
    • Will mRNA vaccines change my genes? No. The vaccines from Moderna and Pfizer use a genetic molecule to prime the immune system. That molecule, known as mRNA, is eventually destroyed by the body. The mRNA is packaged in an oily bubble that can fuse to a cell, allowing the molecule to slip in. The cell uses the mRNA to make proteins from the coronavirus, which can stimulate the immune system. At any moment, each of our cells may contain hundreds of thousands of mRNA molecules, which they produce in order to make proteins of their own. Once those proteins are made, our cells then shred the mRNA with special enzymes. The mRNA molecules our cells make can only survive a matter of minutes. The mRNA in vaccines is engineered to withstand the cell’s enzymes a bit longer, so that the cells can make extra virus proteins and prompt a stronger immune response. But the mRNA can only last for a few days at most before they are destroyed.

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