HONG KONG (BLOOMBERG) – The vaccine made by Sinovac Biotech, one of the most widely used in the world, does not provide sufficient antibodies to neutralise the Omicron variant, said Hong Kong researchers in initial lab findings that may have sweeping consequences for the millions of people relying on the Chinese shot to protect them against Covid-19.
Among a group of 25 people fully vaccinated with the Sinovac shot, none showed sufficient antibodies in their blood serum to neutralise Omicron, said a statement from a team of researchers at the University of Hong Kong that was released late on Tuesday night (Dec 14).
In a separate group of 25 people fully vaccinated with the mRNA shot developed by Pfizer and BioNTech, five of them had neutralising ability against the new variant, the scientists said.
That was in line with findings released last week by the companies, which said a third shot would be sufficient to protect against Omicron.
Led by microbiologist Yuen Kwok Yung, a highly respected professor in infectious diseases at the University of Hong Kong, the study of 50 people has been accepted for publication in medical journal Clinical Infectious Diseases and is available online as a pre-print.
While much is still unknown about how the Sinovac shot reacts to Omicron – including how T-cells, the immune system’s weapon against virus-infected cells, will respond – the findings are a blow to those who have received the 2.3 billion doses of Sinovac shipped out, mostly in China and the developing world.
With Omicron seen to be at least four times as transmissible as the Delta variant in a Japan study, the prospect of having to re-vaccinate against the new strain will set back the world’s efforts to exit the pandemic.
If Sinovac is found in more conclusive studies to be ineffective against Omicron, China, which has managed to insulate the vast majority of its people from Covid-19 with closed borders and strict containment measures, faces the biggest threat from the new variant, said experts.
The Chinese government has given out 2.6 billion home-grown shots – many of them from Sinovac – to its population of 1.4 billion people, but now faces the prospect of having to develop new vaccines and rolling them out again before it can shift away from its current isolationist stance.
Among other countries using the vaccine from Sinovac, previous infection waves would have conferred some natural immunity that will help ensure “no major impact” from Omicron, said epidemiology professor Benjamin Cowling from the University of Hong Kong.
But the populations in mainland China and Hong Kong have experienced no large-scale infection before, leaving them vulnerable.
“The Chinese authorities have worked hard to have a high vaccination rate across the country but the mutability of the virus means that the impact of those efforts has been significantly reduced,” said Associate Professor Nicholas Thomas from the City University of Hong Kong, who has edited several books on foreign policy and public health.
The “twofold challenge” now facing China is how to ensure that its population is again protected from Omicron and any future mutation, plus managing the flows of goods and people over borders when the rest of the world is moving to live with the virus, he said.
China has detected two Omicron cases so far in returning travellers, with one of them being discovered over two weeks after he entered the country.
The Hong Kong research team has exported the isolated Omicron virus to China’s government and vaccine manufacturers for the development of vaccines targeting the new variant, they said.
Sinovac Biotech said last week it was studying how its vaccine holds up against Omicron but gave no timeline for releasing results. The Beijing-based company did not immediately reply to requests for comment on the Hong Kong University findings.
The scientists also advised members of the public to get a third vaccine dose as soon as possible, while awaiting the next generation of shots.
But whether a third dose of the present Sinovac vaccine will improve the neutralising antibody response against the Omicron variant remains to be determined, they said.
Antibodies, which the researchers studied, are one important arm of the immune response protecting people from infection. The other arm of the immune response is cell-mediated immunity – known as T-cell response – which can protect people from serious illness and death.
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