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There is a lane closure in place between junction 13 for Egham and junction 12 for Thorpe in Surrey.
Motorway cameras show significant queues as fire and ambulance work at the scene.
Two lanes – four and five – are currently closed.
Motorway Cameras said normal traffic conditions are expected between 15:45 and 16:00.
National Highways South-East also said there will be planned closures on the M25 on Thursday night.
Clockwise, junctions 3 to 5 & Junctions 6 to 7 will be closed from 10pm to 6am on Friday.
Anti-clockwise, junctions 5 to 4 will also be closed on Thursday night for maintenance works.
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