South Yorkshire Police said the two men, aged 18 and 23, will appear in court today.
Adnan Ashraf Jarral, 35, and his son Usman, one, were killed when Mr Jarral’s Volkswagen Touran people carrier was hit by a Volkwagen Golf which was being pursued by police in Sheffield on Friday evening.
Husband and wife Miroslav Duna, 50, and Vlasta Dunova, 41, also died.
Elliott Bower, 18, who was driving the Golf, has been charged with four counts of causing death by dangerous driving and three counts of causing serious injury by dangerous driving.
He is also charged with handling stolen goods and possession of cannabis.
Declan Bower, 23, of the same address, has been charged with aggravated vehicle-taking and death caused by an accident with aggravated factors.
He is also charged with handling stolen goods, two counts of driving while disqualified, two could of driving without insurance, possession of a bladed article and possession of cannabis.
A 17-year-old boy arrested at the scene in connection to the crash remains in custody.
Nikola Dunova, the daughter of Mr Duna and Ms Dunova, was injured and remains in hospital in a serious but stable condition. Her daughter, aged three, Livia Matova, who was also in the car, is also in hospital.
Mr Jarral’s wife, 32, is also being treated in hospital. On Sunday, Mr Jarral’s uncle, Shafqat Mirza, said she was being treated for a broken leg, back injuries and minor facial injuries.
South Yorkshire Police referred themselves to the Independent Office for Police Conduct after the crash, as one of the vehicles involved was being pursued by officers.
Officers from South Yorkshire Police are helping the office with their investigation.
On Sunday, Mr Mirza, told Sky News his nephew was a “unique character, very humble, very polite – he was full of life and devoted to his sons. He would do anything for them”.
“He was always taking them out on trips, shopping, fun fairs… he was very, very close to his kids.”
He also revealed Mr Jarral and his wife had been planning a trip to Mecca on 27 November.
:: Anyone with information should call 101 quoting incident number 741 of 9 November 2018.
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