TCR2 Therapeutics Reports Positive Interim Results From Ongoing Phase 1 Portion Of Gavo-cel Trial
TCR2 Therapeutics Inc. (TCRR) announced positive interim results from the ongoing phase 1 portion of the gavo-cel phase 1/2 clinical trial for mesothelin-expressing solid tumors. The company is very encouraged by the progression free survival and overall survival observed among patients with refractory mesothelioma treated so far with gavo-cel in the phase 1 trial. Gavo-cel was generally well tolerated with a manageable adverse event profile in the study.
The primary objectives of the phase 1 portion of the trial are to define the safety profile of gavo-cel in patients whose tumors overexpress mesothelin and to determine the recommended phase 2 dose. The company said the recommended phase 2 dose is being refined after identification of the maximum tolerated dose.
Alfonso Quintás-Cardama, Chief Medical Officer of TCR2, said: “Based on these data and the most recent patient experiencing a very mild safety profile at a cell dose of 3×108/m2, we believe the identification of the recommended phase 2 dose is close at hand.”
Shares of TCR2 Therapeutics were up 4% in pre-market trade on Friday.
IronNet Cybersecurity Touches Year-to-date High
IronNet Cybersecurity, Inc. (IRNT) shares are rising on Thursday morning trade, with a continuous uptrend. The shares reached a year-to-date high, after reaffirming revenue and annual recurring revenue or ARR for fiscal 2022 on September 14.
The provider of cybersecurity through collective defense continues to expect fiscal 2022 revenue in a range of $43-$45 million and ARR of 75 million as of the end of the fiscal year.
Currently, shares are at $38.90, up 21.07 percent from the previous close of $32.13 on a volume of 25,871,848. For the 52-week period, the shares have traded in a range of $9.36-$45.81 on average volume of 2,351,198.
Michael K. Williams could win an acting award posthumously.
Michael K. Williams, the beloved star of “The Wire” who was found dead on Sept. 6, is nominated for best supporting actor in a drama for the recently canceled HBO series “Lovecraft Country.” If he does win — and he is a slight favorite over Tobias Menzies from “The Crown” — it will not be because Emmys voters wanted to give him the award posthumously. The Emmy voting period ended before Williams’s death.
Grifols To Acquire Biotest AG In Germany
Grifols (GRFS) has reached an agreement with Tiancheng International Investment Ltd. to acquire 100% of the shares of Tiancheng (Germany) Pharmaceutical Holdings AG, German company owner of 89.88% of Biotest ordinary shares and 1.08% of Biotest preferred shares, for 1.1 billion euros. The deal values Biotest’s equity at 1.6 billion euros. Parallel to the transaction, Grifols launches a voluntary public tender offer to acquire Biotest’s remaining ordinary and preferred shares for 43.00 euros and 37.00 euros, respectively.
Headquartered in Dreieich, Germany, Biotest AG develops, produces and markets biological medicinal products with applications in hematology, clinical immunology and intensive care. Its current portfolio includes 12 different products with a global commercial footprint in more than 90 countries. Biotest has a manufacturing capacity of up to 1.5 million liters of plasma annually.
By 2024, Grifols expects combined revenues of over 7 billion euros, and more than 2 billion euros in EBITDA. The company anticipates notable increase in revenues and profit margins starting in 2023 through new product launches.
New Book Reveals Trump’s Apoplectic Reaction To McConnell Congratulating Biden
Donald Trump “spewed expletives” at then-Senate Majority Leader Mitch McConnell (R-Ky.) after McConnell congratulated Joe Biden on his election victory in a speech on the Senate floor, Washington Post journalists Bob Woodward and Robert Costa write in their upcoming book “Peril.”
Trump was apoplectic with McConnell for his congratulatory Dec. 15 comments and berated him in a furious telephone call as disloyal, according to excerpts from the book that Insider published Thursday.
“You lost the election, the Electoral College has spoken,” McConnell told Trump.
The Kentucky Republican hoped it would “be the final time he and Trump would ever speak to each other,” wrote Woodward and Costa.
Trump and McConnell have since repeatedly traded insults and criticism in speeches and reported comments, but until April at least had not spoken directly for months.
Trump had similar enraged responses to House Minority Leader Kevin McCarthy’s (R-Calif.) criticism of his incitement of the U.S. Capitol riot and former House Speaker Paul Ryan’s (R-Wis.) condemnation of white supremacy, per the book that’s released next week.
Broncos game balls and notable quotes from Week 2 win in Jacksonville
Juratoys Recalls Janod Children’s Shaving Kits Toys
Juratoys has recalled about 13,600 Janod children’s shaving kits toys due to violation of federal phthalate ban.
According to the U.S. Consumer Product Safety Commission, the brown trim of the shaving kit bags contains levels of a regulated phthalate that exceed the prohibition of specific phthalates.
Phthalates are a group of chemicals used to make plastics more durable. Phthalates are in hundreds of products, such as vinyl flooring, lubricating oils, and personal-care products. Banned phthalates are toxic if ingested by young children and can cause adverse health issues.
The recall involves Janod Shaving Kit toys. The kit’s blue fabric zippered bag with brown trim and imitation leather handle holds the following wood components: mustache-shaped scissors, mirror, mustache-shaped comb, cologne bottle, shaving brush, shaving cream bottle and shaver.
The company has not received any incidents regarding the recalled products, but has asked customers to immediately stop using the product and return it to the place of purchase for a full refund.
The product was sold at Nordstrom, Crate and Barrel, and Barnes and Noble stores nationwide as well as on online at Amazon.com, Maisonnette.com, Nordstrom.com, CrateandBarrel.com, and Bn.com for about $30.